In genetics, loss of heterozygosity (LOH) is a type of genetic abnormality in diploid organisms in which one copy of an entire gene and its surrounding chromosomal region are lost. [1] .

3 days ago · LOH (short for “loss of heterozygosity”) refers to a type of mutation that results in the loss of one copy of a segment of DNA (typically containing a gene or group of genes).

Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of …

To determine the presence of loss of heterozygosity (LOH) of the long arm of chromosome 18 (18q) that results in inactivation of tumor suppressor genes and is often associated with hereditary non …

When the loss of heterozygosity involves the normal allele, it creates a cell that is more likely to show malignant growth if the altered gene is a tumor suppressor gene. Also called LOH.

Loss of heterozygosity (LOH) is defined as the loss of a normal allele at a specific locus in a cell’s genome that already contains a deleterious mutation on the corresponding allele.

May 26, 2025 · Loss of Heterozygosity (LOH) is a critical concept in genetics that plays a significant role in cancer development and tumor suppressor gene inactivation. In this comprehensive guide, we will …